Effects at the cellular level.
By mimicking the biological processes of natural tooth development, Straumann® Emdogain forms an insoluble three dimensional extra-cellular matrix. This matrix remains on the root surface for 2-4 weeks and allows for the selective colonization, proliferation and differentiation of cells.
| Days | Weeks | |||
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The amelogenins form a matrix layer on the root surface. Contact to cells of the healthy part of the desmo-dontium is established. |  |
The cells secrete natural and specific cytokines and autokrine substances, which promote the required proliferation. | |
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Adduction and proliferation of mesenchymal cells from the healthy part of the desmodontium. |  |
Attraction and differentiation to cementoblasts, begin of formation of the cement matrix in which the desmodontal fibres will be fixed. | |
| Months | One year | |||
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Anchoring of desmodontal fibers in the root surface. |  |
Regeneration of the desmodontium; a new functional attachment has been formed. | |
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Filling of defect with newly formed desmodontal tissue. |  |
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New alveolar bone grows on the root surface and in the defect gap. |
